Carlisle 200 follows Native bikers Guarina Lopez (Pascua Yaqui) and Tsinnijinnie Russell (Diné) on a 200-mile prayer ride from Washington, D.C. to the cemetery at Carlisle Indian Boarding School in Carlisle, PA. Through rain and shine on the long gravel trail, Guarina, Tsinnijinnie, and fellow activist-bikers honor the 190+ children buried at Carlisle and raise awareness of the history and ongoing impact of the residential boarding school system on Indigenous communities.